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Medscape – Major depressive disorder dosing for Pristiq (desvenlafaxine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. A generic form of Pristiq may become available in 2022. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Get Desvenlafaxine Succinate ER for as low as $19.80, which is 90% off the average retail price of $194.83 for the most common version, by using a GoodRx coupon. Pristiq side effects often include nausea, dry mouth, sleep changes, and sexual issues. Know when to call your doctor and how to manage them. Pristiq (desvenlafaxine) is a brand-name prescription drug that's used to treat depression in adults. Learn about side effects, warnings, dosage, and more. The Pristiq dosage maximum is 400mg/day, but 50mg is standard. Learn about safe limits, side effects, and dose adjustments for specific health conditions. 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