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FREE SHIPPING for Prime members. Powerful, 24-hour, non-drowsy indoor and outdoor allergy relief Provides relief of symptoms triggered by over 200 different allergens from pets, pollen, dust and mold. Claritin is an antihistamine so it hinders the cascade triggered by allergens Relief of your worst allergy symptoms including sneezing, runny nose, itchy and watery eyes and itchy throat or nose Contains 10 mg of loratadine per … Clarinex can take one to three hours to work and reaches peak concentration at the three hour mark. It can last 27 hours, which helps provide all day relief from allergy symptoms. [1] It's best to take Clarinex a couple of hours before you plan to go outside, allowing it to start working before you're exposed to pollen. Clarinex is a histamine-1 (H1) receptor antagonist that contains an antihistamine to treat allergic rhinitis and chronic idiopathic urticaria. 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